27-Hydroxycholesterol (27-HC) is a metabolite resulting from the action of sterol 27-Hydroxylase on cholesterol. It is an endogenous selective estrogen receptor modulator and ligand for the liver X receptor (LXR). 27-Hydroxycholesterol plays a role in Alzheimer's disease, oxidative stress, metabolism, cell-signaling, and heart disease. Alternative name: 5,25R-Cholesten-3β,26-diol, (25R)-26-Hydroxycholesterol. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (up to 10 mg/ml with warming) or in ethanol (up to 10 mg/ml). Insoluble in water. Long Term Storage: -20°C.